Poster Presentation 33rd ASM of the Australian & New Zealand Bone & Mineral Society 2023

Investigating early-onset osteoporosis in individuals with Down syndrome (#216)

Michelle Maugham-Macan 1 , Bridgette O'Malley 1 , Georgia Kafer 1
  1. University of the Sunshine Coast, Sippy Downs, QLD, Australia
Publish consent withheld
  1. 1. de Graaf, G., F. et al., Genet Med, 2017. 19(4): p. 439-447.
  2. 2. Down Syndrome Statistics in Australia. 2011 19 June 2023.
  3. 3. Sherman, K.M., et al., Low bone mass and impaired fracture healing in mouse models of Trisomy21 (Down syndrome). Bone, 2022. 162: p. 116471.
  4. 4. Lee, Y., et al., Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis. Journal of Biological Chemistry, 2009. 284(48): p. 33343-33351.
  5. 5. LaCombe, J.M. and R.J. Roper, Skeletal dynamics of Down syndrome: A developing perspective. Bone, 2020. 133: p. 115215.
  6. 6. Fowler, T.W., et al., Low Bone Turnover and Low BMD in Down Syndrome: Effect of Intermittent PTH Treatment. PLOS ONE, 2012. 7(8): p. e42967.
  7. 7. González-Agüero, A., et al., Bone mass in male and female children and adolescents with Down syndrome. Osteoporosis International, 2011. 22(7): p. 2151-2157.
  8. 8. Garcia-Ramírez, M., et al., Down's Syndrome: Altered Chondrogenesis in Fetal Rib. Pediatric Research, 1998. 44(1): p. 93-98.
  9. 9. Kjaer, M.S., et al., Hand development in trisomy 21. Am J Med Genet, 1998. 79(5): p. 337-42.